[Electroacupuncture activates PKA / CREB signaling pathway to promote browning of white fat in obese rats].
EA can effectively reduce the body weight and improve lipid metabolism in obesity rats, which is possibly associated with its functions in activating the PKA/CREB signalling pathway, up-regulating the white fat browning markers UCP1 and PGC-1α protein expressions and white fat browning-related genes, and down-regulating the expression of the lipid regulatory protein SREBP-1.
Authors
- He-Jing Liu
- Jun-Yuan Deng
- Chenglin Tang (ORCID: https://orcid.org/0009-0004-7151-3564)
- Yan Yang (ORCID: https://orcid.org/0000-0003-2224-2556)
- Cai Liao
- Wei Qiu
- Yunhao Yang (ORCID: https://orcid.org/0000-0002-7199-2508)
- Jue Wang (ORCID: https://orcid.org/0000-0002-3641-3136)
Institutions
- First People's Hospital of Chongqing (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-05-25
- DOI
- https://doi.org/10.13702/j.1000-0607.20240755
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article