INTENSITY OF FREE RADICAL PROCESSES IN THE BLOOD PLASMA OF COMBATANTS AFTER COMBAT INJURY OF THE MUSCULOSKOLE SYSTEM

Background. As a result of the full-scale war in Ukraine, which began in 2022, many servicemen have been negatively affected by various factors of combat activity. The use of high-tech means and innovative technologies of combat leads to a high level of combat injuries of the musculoskeletal system by combatants. The study of the course of the wound process and the strategy for its effective treatment is of particular relevance. The speed of recovery of patients and the prevention of the development of local and systemic complications associated with such injuries depend on this. Tissue damage and the development of inflammation in them are associated with a violation of the oxidative-antioxidant balance in the body. This leads to the development of oxidative stress and damage to biological molecules. Therefore, the aim of the work was to determine the intensity of free radical processes in the blood plasma of combatants after combat injuries of the musculoskeletal system. Methods. All study participants were further divided into two experimental groups, the average age of patients in each group was the same. The first group (n=10) included conditionally healthy people. The second group (n = 10) – patients with gunshot wounds to the joint. In the blood plasma of patients, the concentration of superoxide radical, hydrogen peroxide, diene conjugates, TBA-active compounds and Schiff bases was determined by generally accepted biochemical methods. The results of the study were processed by generally accepted methods of variational statistics. Results. During the experimental studies we conducted, it was shown that in the blood plasma of patients with combat trauma of the musculoskeletal system, the formation of superoxide radical increases by 2.6 times and hydrogen peroxide by 2.3 times compared to the indicators of a group of conditionally healthy people. Under the same experimental conditions, an increase in lipid peroxidation products was detected: diene conjugates by 2.7 times, TBA-active compounds by 2.5 times and Schiff bases by 2.4 times compared to conditionally healthy people. Conclusions. The results obtained indicate the development of oxidative stress in the blood plasma of patients with combat trauma of the musculoskeletal system.