Multi-line lateral flow immunoassay for the detection and subtyping of breast cancer-derived small extracellular vesicles
Cancer cell-derived small extracellular vesicles (sEVs) are new promising biomarkers for improved cancer diagnosis. A multi-line lateral flow immunoassay (LFIA) has been proposed for sensitive detection and subtyping of breast cancer-derived sEVs. The expression of cancer surface biomarkers (EpCAM) was confirmed through colorimetric analysis of cell line-derived sEVs (<i>p</i> = 0.076) and patient samples, highlighting the potential for their use as a clinical aid.
Authors
- David W. Inglis (ORCID: https://orcid.org/0000-0001-8239-5568)
- Laura M. Rey Gomez (ORCID: https://orcid.org/0000-0002-6862-3533)
- Chloe Duffield (ORCID: https://orcid.org/0000-0003-4059-3819)
- Simon Chang‐Hao Tsao (ORCID: https://orcid.org/0000-0002-9654-359X)
- Su Su Thae Hnit (ORCID: https://orcid.org/0000-0002-3218-8832)
- Yuling Wang (ORCID: https://orcid.org/0000-0003-3627-7397)
- Wei Zhang (ORCID: https://orcid.org/0000-0001-7005-5726)
Institutions
- The University of Melbourne (AU)
- Austin Health (AU)
- Macquarie University (AU)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01038a
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Australian Research Council
- Cancer Council NSW