Comparison of the pathogenicity of multiple <scp>SARS</scp>‐<scp>CoV</scp>‐2 variants in mouse models
In hACE2 mice, the Omicron variant demonstrated the lowest pathogenicity, while the Beta variant exhibited the highest. Pathogenicity of the Delta variant was comparable to the original WH-09 strain. Among BALB/c mice, Omicron subvariants BA.5, BF.7, and XBB.1 showed no statistically significant differences in virulence.
Authors
- Ming Liu (ORCID: https://orcid.org/0000-0001-7796-7197)
- Mingya Liu
- Feifei Qi
- Qi Lv (ORCID: https://orcid.org/0000-0003-2102-2877)
- Linlin Bao (ORCID: https://orcid.org/0000-0003-4869-3777)
- Shuyue Li (ORCID: https://orcid.org/0000-0001-6459-239X)
- Ran Deng
- Xujian Liang (ORCID: https://orcid.org/0009-0009-8806-4343)
- Guocui Mou
- Yanfeng Xu
- Zhiqi Song (ORCID: https://orcid.org/0000-0001-8628-2309)
- Fengdi Li
- Yiwei Yan (ORCID: https://orcid.org/0000-0003-3794-1106)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Model Animal Research Center (CN)
- Institute of Laboratory Animal Science (CN)
Publication Details
- Journal
- Animal Models and Experimental Medicine
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1002/ame2.70029
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China