Second-harmonic generation microscopy of murine scleral remodeling by collagenase and reparative collagen mimetic peptides
CMP treatment induced scleral collagen reorganization after collagenase digestion in murine models. These effects are consistent with inhibition or reversal of collagen enzymatic digestion. These results suggest that specific CMPs may have utility in the treatment of progressive myopia.
Authors
- Daniel E. Savage
- Jiaxi Zhou (ORCID: https://orcid.org/0000-0003-2835-7178)
- Brian J. Del Buono (ORCID: https://orcid.org/0000-0002-9089-2131)
- James A. Germann
- Michael Telias (ORCID: https://orcid.org/0000-0002-7632-6942)
- Robert O. Baratta (ORCID: https://orcid.org/0000-0002-7241-8647)
- Susana Marcos (ORCID: https://orcid.org/0000-0001-5511-1697)
- Mark R. Buckley (ORCID: https://orcid.org/0000-0002-6938-2110)
- Eric Schlumpf (ORCID: https://orcid.org/0000-0001-5424-878X)
- Aldo Tecse
Institutions
- University of Utah (US)
- University of Rochester (US)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-05-20
- DOI
- https://doi.org/10.3389/fmed.2025.1514073
- Primary Topic
- Photoacoustic and Ultrasonic Imaging
- Type
- article
- Field-Weighted Citation Impact
- 0.00