Single-cell RNA sequencing identifies two fibroblast subtypes and a Trem2+ macrophage subtype as the possible specific cellular targets in abdominal aortic aneurysms
Our findings revealed distinct evolutionary pathways for both fibroblasts and macrophages, leading to the identification of specific fibroblast subtypes (Fib_Apoc1<sup>+</sup>/Fabp4<sup>+</sup> and inflam-Fib1) and a macrophage subtype (Mac_TREM2). Cellular interactome analysis further reveals that fibroblasts and macrophages may play a certain synergistic role in the development of AAA. This study provides a comprehensive characterization of the transcriptional landscape of AAA and identifies novel therapeutic targets.
Authors
- Liqiang Cui (ORCID: https://orcid.org/0000-0002-3601-7264)
- Yuehong Zheng (ORCID: https://orcid.org/0000-0002-0704-5469)
- Ben Wang (ORCID: https://orcid.org/0000-0002-1191-4591)
- Wei Ye (ORCID: https://orcid.org/0000-0002-6994-4697)
- Rong Zeng (ORCID: https://orcid.org/0009-0006-1183-5304)
- Xiaojun Song (ORCID: https://orcid.org/0000-0001-9906-0377)
- Zhili Liu (ORCID: https://orcid.org/0009-0003-2623-1325)
Institutions
- Army Medical University (CN)
- Daping Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1551308
- Citations
- 3
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.56