Recharacterization of the Tumor Suppressive Mechanism of RSL3 Identifies the Selenoproteome as a Druggable Pathway in Colorectal Cancer
Chemoproteomic profiling reveals that RSL3 functions through pan-selenoprotein inhibition beyond GPX4 and identifies ALKBH8, a tRNA-selenocysteine methyltransferase essential for selenoprotein translation, as a therapeutic target to disrupt redox balance in colorectal cancer. See related commentary by Short, p. 2775.
Authors
- Wai‐Lung Ng (ORCID: https://orcid.org/0000-0003-2892-6318)
- Zachary T. Schafer (ORCID: https://orcid.org/0000-0001-9227-3118)
- Nicholas J. Rossiter (ORCID: https://orcid.org/0000-0001-7333-1546)
- Andrii Balia (ORCID: https://orcid.org/0000-0002-1443-6572)
- Nouri Neamati (ORCID: https://orcid.org/0000-0003-3291-7131)
- João A. Paulo (ORCID: https://orcid.org/0000-0002-4291-413X)
- Stephen L. DeAngelo (ORCID: https://orcid.org/0000-0002-7984-5780)
- Marwa O. El-Derany (ORCID: https://orcid.org/0000-0002-1552-9607)
- Yatrik M. Shah (ORCID: https://orcid.org/0000-0002-2487-4816)
- Nupur K. Das (ORCID: https://orcid.org/0000-0002-5652-1134)
- Sumeet Solanki (ORCID: https://orcid.org/0000-0002-2773-3082)
- Indrani Talukder (ORCID: https://orcid.org/0000-0002-4144-3815)
- Hannah N. Bell (ORCID: https://orcid.org/0000-0003-2609-5557)
- Yuezhong Zhang (ORCID: https://orcid.org/0000-0002-8827-0114)
- Joseph Douglas Mancias (ORCID: https://orcid.org/0000-0002-0692-3717)
- Markos Koutmos (ORCID: https://orcid.org/0000-0003-0933-6312)
- Sofia Dziechciarz (ORCID: https://orcid.org/0009-0001-8843-0691)
- Jianping He (ORCID: https://orcid.org/0009-0001-6177-4179)
- Yao Qin
- Liang Zhao (ORCID: https://orcid.org/0009-0004-5999-8976)
- Cristina Castillo (ORCID: https://orcid.org/0000-0001-6125-1813)
- Elizabeth C. McCulla (ORCID: https://orcid.org/0009-0003-2583-0094)
- Myungsun Shin
Institutions
- University of Notre Dame (US)
- Ain Shams University (EG)
- Harvard University (US)
- Chinese University of Hong Kong (HK)
- University of Michigan (US)
- Harvard University Press (US)
- Michigan United (US)
- Michigan Medicine (US)
- Dana-Farber Cancer Institute (US)
- Michigan Center for Translational Pathology (US)
- Ann Arbor Center for Independent Living (US)
- Harvard Stem Cell Institute (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3478
- Citations
- 14
- Primary Topic
- Selenium in Biological Systems
- Type
- article
- Field-Weighted Citation Impact
- 15.67
Funders
- American Heart Association
- Crohn's and Colitis Foundation
- Comprehensive Cancer Center, University of Michigan
- National Cancer Institute
- National Institute of General Medical Sciences
- National Institute of Diabetes and Digestive and Kidney Diseases