Reactivating cGAS–STING Signaling by Targeting SOS1 Enhances Antitumor Immunity in <i>NRAS</i> -Mutant Tumors
Suppression of innate immune signaling in NRAS-mutant tumors results from downregulation of the cGAS-STING axis and can be reversed using SOS1 inhibitors combined with STING agonists to restrain NRAS-mutant tumor growth.
Authors
- Xiao‐Feng Zhu (ORCID: https://orcid.org/0000-0002-1250-0796)
- Tian Du (ORCID: https://orcid.org/0000-0003-0841-6484)
- Kai-Ming Zhang (ORCID: https://orcid.org/0000-0002-8195-1136)
- Yu-Hong Chen
- Hai‐Liang Zhang (ORCID: https://orcid.org/0009-0006-0098-7580)
- Rong Deng (ORCID: https://orcid.org/0000-0003-3724-0326)
- Jia‐Lu Shan
- Zhi‐Ling Li
- Wen-Qing Zhong
- Yun Huang (ORCID: https://orcid.org/0000-0001-6963-3728)
- Jia‐Hong Tang
- Dong Yang (ORCID: https://orcid.org/0000-0002-4358-9631)
- Xiao-Yu Yang
Institutions
- Sun Yat-sen University (CN)
- Key Laboratory of Guangdong Province (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
- State Key Laboratory of Oncology in South China
Publication Details
- Journal
- Cancer Research
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1158/0008-5472.can-24-2983
- Citations
- 1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80