Marked mucosal lipid shifts in treatment refractory inflammatory bowel disease: a lipidomic study
The mucosal lipid profile of treatment refractory UC shows marked shifts compared to treatment naïve UC at debut with moderate to severe inflammation. These are novel findings which possibly indicate dynamic processes of long-standing mucosal inflammation. The mucosal lipid profile of IBD patients in remission seems to be similar to the normal state.
Authors
- Jon Florholmen
- Mona D. Gundersen (ORCID: https://orcid.org/0000-0002-1813-5187)
- Oddmund Nestegard (ORCID: https://orcid.org/0000-0002-7439-575X)
- Dawei Geng (ORCID: https://orcid.org/0000-0002-8553-8824)
- Thomas Möritz (ORCID: https://orcid.org/0000-0002-4258-3190)
- Rasmus Goll (ORCID: https://orcid.org/0000-0003-4375-0509)
- Øystein K. Moe
- Qian Gao (ORCID: https://orcid.org/0009-0002-9974-1273)
- Einar Jensen
Institutions
- University of Copenhagen (DK)
- University Hospital of North Norway (NO)
- Vestre Viken Hospital Trust (NO)
- Novo Nordisk Foundation (DK)
- Swedish University of Agricultural Sciences (SE)
- UiT The Arctic University of Norway (NO)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1186/s12876-025-03944-6
- Citations
- 2
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Universitetet i Tromsø
- Helse Nord RHF
- Novo Nordisk Fonden