Enhancing the CuAAC efficiency of a Cu(<scp>i</scp>)–NHC complex in biological media by encapsulation
A novel [(NHC)<sub>2</sub>Cu]Br (Cu(I)-NHC) complex promotes CuAAC reactions in organic solvents, water, buffers and even complex biological media in good yields. Encapsulation of the Cu catalyst in an amphiphilic polymer enhances its performance in complex media, increases catalyst stability in the presence of glutathione and reduces cytotoxicity in HeLa cells.
Authors
- Anja R. A. Palmans (ORCID: https://orcid.org/0000-0002-7201-1548)
- A. P. Prakasham
- Harshit Singh (ORCID: https://orcid.org/0000-0002-4548-1528)
Institutions
- Eindhoven University of Technology (NL)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01891a
- Citations
- 3
- Primary Topic
- Quantum-Dot Cellular Automata
- Type
- article
- Field-Weighted Citation Impact
- 4.51
Funders
- European Commission
- Technische Universiteit Eindhoven
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek