Hybrid B- and T-Cell Immunity Associates With Protection Against Breakthrough Infection After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Avon Longitudinal Study of Parents and Children (ALSPAC) Participants
Collectively, these results suggest that hybrid B- and T-cell immunity offers superior protection from BI after coronavirus disease 2019 (COVID-19) vaccination, and this finding has implications for designing next-generation COVID-19 vaccines that are capable of eliciting immunity to a broader repertoire of SARS-CoV-2 proteins.
Authors
- Linda Wooldridge (ORCID: https://orcid.org/0000-0002-6213-347X)
- Anthony Brown (ORCID: https://orcid.org/0000-0002-1448-0899)
- Susan M. Ring (ORCID: https://orcid.org/0000-0003-3103-9330)
- Natalie Di Bartolo (ORCID: https://orcid.org/0000-0002-9389-8416)
- Ashley M. Toye (ORCID: https://orcid.org/0000-0003-4395-9396)
- Laura Rivino (ORCID: https://orcid.org/0000-0001-6213-9794)
- Paul Klenerman (ORCID: https://orcid.org/0000-0003-4307-9161)
- Kapil Gupta (ORCID: https://orcid.org/0000-0002-2115-3503)
- Amy Thomas (ORCID: https://orcid.org/0000-0002-2658-4126)
- Milla Kibble (ORCID: https://orcid.org/0000-0003-1130-4010)
- Adam Finn (ORCID: https://orcid.org/0000-0003-1756-5668)
- Jennifer Oliver
- Lynn Molloy
- Ore Francis (ORCID: https://orcid.org/0000-0003-2678-917X)
- Ruth E. Mitchell (ORCID: https://orcid.org/0000-0002-3506-160X)
- Kate Northstone (ORCID: https://orcid.org/0000-0002-0602-1983)
- Alice Halliday (ORCID: https://orcid.org/0000-0001-8183-1110)
- Emily Milodowski (ORCID: https://orcid.org/0000-0001-8452-1177)
- Elizabeth Oliver (ORCID: https://orcid.org/0000-0002-1211-1942)
- Anu Goenka (ORCID: https://orcid.org/0000-0002-8152-2155)
- Nicholas J. Timpson (ORCID: https://orcid.org/0000-0002-7141-9189)
- Holly E. Baum (ORCID: https://orcid.org/0000-0002-1311-6446)
- Benjamin Hitchings (ORCID: https://orcid.org/0000-0001-5248-9061)
- Marianna Santopaolo (ORCID: https://orcid.org/0009-0008-7593-287X)
- Andrew D. Davidson (ORCID: https://orcid.org/0000-0002-1136-4008)
- Begonia Morales‐Aza (ORCID: https://orcid.org/0000-0003-4760-543X)
- Melanie Lewcock
- Imre Berger (ORCID: https://orcid.org/0000-0001-7518-9045)
- Firona Roth
- Divya Diamond
- Katrina Entwistle
Institutions
- King's College London (GB)
- University of Cambridge (GB)
- Bristol Royal Hospital for Children (GB)
- University of Bristol (GB)
- University of Oxford (GB)
- Medawar Building for Pathogen Research (GB)
- Health & Life (Taiwan) (TW)
- Medical Research Council (GB)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-05-15
- DOI
- https://doi.org/10.1093/infdis/jiaf246
- Citations
- 2
- Primary Topic
- Health, Environment, Cognitive Aging
- Type
- article
- Field-Weighted Citation Impact
- 2.40
Funders
- Wellcome Trust
- UK Research and Innovation
- Academy of Medical Sciences
- University of Bristol
- Musculoskeletal Research Center, Washington University in St. Louis
- Elizabeth Blackwell Institute for Health Research, University of Bristol
- Medical Research Council