Epitope specificity of antibody-mediated protection induced in mice by the malaria vaccine RTS,S/AS01
Antibodies induced by the malaria vaccine RTS,S/AS01 neutralize infectivity of transgenic sporozoites expressing Plasmodium falciparum CSP (PfCSP). These antibodies recognize the junctional, minor repeats, central repeats, and C-term regions of this antigen. The epitope specificity of antibodies mediating protection in mice was characterized in vivo using transgenic sporozoites expressing restricted antigenic portions of PfCSP. In this model, we found protection is mediated mostly by antibodies specific for the central repeats.
Authors
- Ian A. Wilson (ORCID: https://orcid.org/0000-0002-6469-2419)
- Berenice Salgado-Jimenez
- Shamika Mathis-Torres
- Fidel Zavala (ORCID: https://orcid.org/0000-0002-1414-6196)
- Minah Park (ORCID: https://orcid.org/0000-0001-9889-3350)
- Re’em Moskovitz
- Yevel Flores-García (ORCID: https://orcid.org/0000-0001-7230-3834)
- Randall S. MacGill (ORCID: https://orcid.org/0000-0002-4566-1481)
- Emily Locke (ORCID: https://orcid.org/0000-0003-1944-8473)
Institutions
- Scripps Research Institute (US)
- Program for Appropriate Technology in Health (US)
- Johns Hopkins University (US)
Publication Details
- Journal
- npj Vaccines
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1038/s41541-025-01162-5
- Citations
- 1
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- United States Agency for International Development
- Bill and Melinda Gates Foundation
- PATH
- Johns Hopkins University
- Bloomberg Philanthropies