PSME2 promotes malignant progression through autophagy modulation via IL-6/STAT3 signaling pathway in esophageal squamous cell carcinoma
The study shows the promising role of PSME2 as a therapeutic target in ESCC management. The combined inhibition of PSME2 and activated pathways ensures effective suppression of tumor growth and proliferation, thus offering a novel strategy for better treatment outcomes in ESCC patients.
Authors
- Young‐Hee Kang (ORCID: https://orcid.org/0000-0003-2039-7968)
- Meng-Xiang Li
- Chunhui Qi
- Zi-Chao Zhang (ORCID: https://orcid.org/0000-0001-5747-3093)
- Yongxuan Liu (ORCID: https://orcid.org/0000-0002-8856-9044)
- Xiao-Shuang Wu
- Yijun Qi (ORCID: https://orcid.org/0000-0003-0239-5862)
- Di Zhao (ORCID: https://orcid.org/0009-0000-4434-5404)
- Yunyan Du (ORCID: https://orcid.org/0000-0002-2448-9520)
- Kui Sun (ORCID: https://orcid.org/0009-0006-1719-3701)
- Shegan Gao
Institutions
- Henan Cancer Hospital (CN)
- Luoyang Institute of Science and Technology (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1016/j.lfs.2025.123749
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China