Atypical Presentation of Liver Metastasis in Medullary Thyroid Carcinoma: Variable Pattern and Interlesional Heterogeneity Observed on 18F-FDG, 68Ga-DOTATATE, and 68Ga-DOTA-FAPI-04 PET/CT
Metastatic medullary thyroid carcinoma (MTC) can exhibit variable progression, with liver metastases occurring in up to 62% of cases. We report an unusual case of 50-year-old man with progressive MTC and atypical hypodense metastasis in the left lobe of liver that showed no tracer avidity on conventional 18 F-FDG and 68 Ga-DOTATATE PET/CT but was intensely avid on 68 Ga-DOTA-FAPI-04 PET/CT, implying a possible role of FAPI PET/CT imaging in diagnosing unusual metastatic lesions that may be missed on conventional PET imaging and also its theranostic potential for future management.
Authors
- Rahul V. Parghane
- Sandip Kanti Basu (ORCID: https://orcid.org/0000-0001-6607-2558)
- Gaurav Malhotra (ORCID: https://orcid.org/0000-0001-8393-4949)
- Shyam Kumar Ravada
Institutions
- Bhabha Atomic Research Centre (IN)
- Homi Bhabha National Institute (IN)
- Tata Memorial Hospital (IN)
Publication Details
- Journal
- Clinical Nuclear Medicine
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1097/rlu.0000000000005965
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00