Chronic Alteration in Cerebral FDG Metabolism After MRI-guided HIFU for Essential Tremor
A 74-year-old man with a history of monoclonal gammopathy of undetermined significance (MGUS) underwent surveillance whole-body 18 F-FDG PET 2 weeks before MRI-guided high-intensity focused ultrasound (MRgHIFU) of the left dentato-rubro-thalamic tract (DRTT) for his right-hand dominant, debilitating essential tremor. This baseline FDG PET showed normal thalamic metabolism. At 12 months post-treatment, FDG PET scan revealed a small focus of left thalamic hypometabolism, which corresponded to the left DRTT ablation area seen on post-treatment MRI. The patient was tremor-free in his right hand at 1-year follow-up. This case documents the chronic effects of MRgHIFU on cerebral FDG metabolism.
Authors
- Fabrício Stewan Feltrin (ORCID: https://orcid.org/0000-0001-6783-7655)
- Orhan K. Öz (ORCID: https://orcid.org/0000-0002-5846-6829)
- Bhavya Shah (ORCID: https://orcid.org/0000-0002-0058-6174)
- Nghi Nguyen (ORCID: https://orcid.org/0000-0001-8458-0062)
- Alexander Asturias (ORCID: https://orcid.org/0000-0001-8656-2749)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Clinical Nuclear Medicine
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1097/rlu.0000000000005987
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00