Mycobacteroides abscessus subspecies: a comparative genomic analysis reveals unique metabolic activities and drug resistance patterns
Through comparative genomic analysis, we revealed the unique metabolic activities of M. abscessus subsp. abscessus and M. abscessus subsp. massiliense, providing a scientific basis for future diagnostic and personalized management strategies. Identifying possible novel amikacin and moxifloxacin resistance genes within these subspecies offers insights for future drug development efforts and enhances our understanding of the mechanisms underlying M. abscessus drug resistance.
Authors
- Shunying Liu (ORCID: https://orcid.org/0000-0002-3894-757X)
- Yaokai Chen (ORCID: https://orcid.org/0000-0003-3403-9782)
- Zhenyu Kou
- Fangjie Wang
- Xiaoyu Wang (ORCID: https://orcid.org/0000-0002-8641-2430)
- Xiao Wang (ORCID: https://orcid.org/0000-0002-5893-5162)
- Liang Wang (ORCID: https://orcid.org/0000-0002-5965-8451)
- Lingfei Li (ORCID: https://orcid.org/0000-0002-7702-1526)
- Lei Xia (ORCID: https://orcid.org/0000-0001-9749-3435)
- Yanhai Feng
- Yongdong Dai (ORCID: https://orcid.org/0000-0003-4333-4273)
Institutions
- Army Medical University (CN)
- Daping Hospital (CN)
- Xinqiao Hospital (CN)
- Shanghai Center For Bioinformation Technology (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1186/s12866-025-04010-7
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Army Medical University