Intravenous SARS-CoV-2 Spike protein induces neuroinflammation and alpha-Synuclein accumulation in brain regions relevant to Parkinson’s disease
Our results demonstrate that S1-protein itself leads to neuroinflammation, altered aSyn homeostasis, and disruption of inhibitory circuits in a route- and sex-dependent manner. These findings indicate the possibility of S1-protein being a crucial agent for both neuroinflammatory processes and altered protein regulation mechanisms. S1-protein trapped in tissue reservoirs could therefore explain symptoms occurring or persisting beyond viral clearance (Post COVID-19 condition).
Authors
- Franziska Richter (ORCID: https://orcid.org/0000-0003-0803-4398)
- Robert Meineke (ORCID: https://orcid.org/0000-0003-4191-8021)
- Cara Sophie Schreiber
- Christopher Käufer
- Lucas Navarro Ramil
- Juliette Bieligk
Institutions
- University of Veterinary Medicine Hannover, Foundation (DE)
- Hannover Re (Germany) (DE)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1016/j.bbi.2025.05.021
- Citations
- 6
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 8.34
Funders
- Niedersächsische Ministerium für Wissenschaft und Kultur
- Studienstiftung des Deutschen Volkes
- Niedersächsisches Ministerium für Wissenschaft und Kultur