Aquaporin 4 and its isoforms regulation ameliorate AQP4 Mis-localization-induced glymphatic dysfunction in ischemic stroke
Cerebral edema disrupts AQP4 localization and glymphatic function following stroke. TGN-020 modulates AQP4 polarization through regulation of AQP4 isoforms and restores glymphatic dysfunction. AQP4-M23 isoform emerges as a key regulator of AQP4 polarization, providing new insights into ischemic stroke pathophysiology.
Authors
- Dingyi Yan
- Wen He Sun (ORCID: https://orcid.org/0000-0002-7268-2085)
- Hanhong Zhang (ORCID: https://orcid.org/0000-0003-0017-8506)
- Pan Zhang (ORCID: https://orcid.org/0000-0002-5486-7537)
- Xinfeng Liu (ORCID: https://orcid.org/0000-0002-8182-9632)
- Jinjing Wang
- Siyuan Zhang (ORCID: https://orcid.org/0009-0004-9067-9850)
- Yiran Dong
Institutions
- University of Science and Technology of China (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1016/j.jare.2025.05.022
- Citations
- 5
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 4.55