Human Physiologic Responses to Insulin in Indigenous Americans Identify a Metabolic Susceptibility Profile Linked to Diabetes
Metabolic signatures of clamp-determined insulin action are strongly associated with incident diabetes, suggesting causal-functional pathways of T2D.
Authors
- Andrew Perry (ORCID: https://orcid.org/0000-0003-3342-6158)
- J. Jeffrey Carr (ORCID: https://orcid.org/0000-0002-4398-8237)
- Lindsey K. Stolze (ORCID: https://orcid.org/0000-0003-2269-769X)
- Ravi V. Shah (ORCID: https://orcid.org/0000-0002-4471-7156)
- Jonathan Krakoff (ORCID: https://orcid.org/0000-0001-6074-5600)
- Leslie J. Baier (ORCID: https://orcid.org/0000-0002-8773-9670)
- Paolo Piaggi (ORCID: https://orcid.org/0000-0003-2774-9161)
- Robert L. Hanson (ORCID: https://orcid.org/0000-0002-4252-7068)
- James Greg Terry (ORCID: https://orcid.org/0000-0001-6659-3441)
- Clary B. Clish (ORCID: https://orcid.org/0000-0001-8259-9245)
- Clifton Bogardus (ORCID: https://orcid.org/0000-0003-1472-3376)
- Shilin Zhao (ORCID: https://orcid.org/0000-0002-3921-3965)
- Eric R. Gamazon (ORCID: https://orcid.org/0000-0003-4204-8734)
- Venkatesh Locharla Murthy (ORCID: https://orcid.org/0000-0002-7901-1321)
Institutions
- Broad Institute (US)
- University of Michigan (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Michigan Medicine (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Diabetes Care
- Published
- 2025-05-20
- DOI
- https://doi.org/10.2337/dc25-0151
- Citations
- 1
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- American Heart Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Northwestern University
- University of Minnesota
- University of Alabama at Birmingham
- Siemens Healthineers
- National Institutes of Health
- Kaiser Foundation Research Institute
- National Heart, Lung, and Blood Institute
- National Institute of Diabetes and Digestive and Kidney Diseases