Therapeutic time window of sodium of Danshensu on cerebral ischemia and its mechanism of inhibiting oxidative stress and ferroptosis through Nrf2 pathway
The therapeutic time window of SDSS for ischemic stroke is relatively wide. The administration of SDSS can potentially mitigate brain damage through the inhibition of oxidative damage and ferroptosis, which is partly regulated by the Nrf2/GPX4 axis. Therefore, SDSS is a promising candidate for the treatment of ischemic stroke.
Authors
- Aidong Wen (ORCID: https://orcid.org/0000-0002-4535-0501)
- Zhongying Ma (ORCID: https://orcid.org/0000-0002-5202-9775)
- Xingru Tao
- Kai Gao (ORCID: https://orcid.org/0000-0002-0771-7755)
- Chao Guo (ORCID: https://orcid.org/0000-0003-2259-0788)
- Jingwen Wang (ORCID: https://orcid.org/0000-0003-1777-5307)
- Wei Zhang (ORCID: https://orcid.org/0000-0001-8679-6713)
- Yi Ding
Institutions
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111396
- Citations
- 2
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 4.76