Inconsistent primary motor cortex glucose hypometabolism in primary lateral sclerosis
Primary motor cortex hypometabolism in PLS patients is less consistent than previously reported, and the absence of this hypometabolic sign should not be considered as irrefutable evidence against PLS in the diagnostic process. The findings of our study underline the heterogeneity of PLS, indicating that more precise diagnostic tools would be beneficial to confirm a PLS diagnosis at an earlier stage.
Authors
- Annaliis Lehto (ORCID: https://orcid.org/0000-0003-3459-8226)
- Bernd Joachim Krause (ORCID: https://orcid.org/0000-0002-2572-4131)
- Stefan Johannes Teipel (ORCID: https://orcid.org/0000-0002-3586-3194)
- Johannes Prudlo (ORCID: https://orcid.org/0000-0002-7932-5929)
- Julia Schumacher (ORCID: https://orcid.org/0000-0001-7323-4789)
- Elisabeth Kasper (ORCID: https://orcid.org/0000-0003-0583-1236)
- Jens Kurth (ORCID: https://orcid.org/0000-0001-6864-4513)
Institutions
- German Center for Neurodegenerative Diseases (DE)
- Rostocker Zentrum zur Erforschung des Demografischen Wandels (DE)
- University of Rostock (DE)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1007/s00415-025-13089-x
- Citations
- 2
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78