Identification and validation of poly-metabolite scores for diets high in ultra-processed food: An observational study and post-hoc randomized controlled crossover-feeding trial
Poly-metabolite scores, developed in IDATA participants with varying diets, are predictive of UPF intake and could advance epidemiological research on UPF and health. Poly-metabolite scores should be evaluated and iteratively improved in populations with a wide range of UPF intake.
Authors
- Hyokyoung Grace Hong (ORCID: https://orcid.org/0000-0002-4280-6243)
- Lisa Kahle (ORCID: https://orcid.org/0000-0002-1783-7240)
- Caitlin P. O’Connell (ORCID: https://orcid.org/0000-0003-1068-4584)
- Eleanor L. Watts (ORCID: https://orcid.org/0000-0001-9229-2589)
- Leila Abar (ORCID: https://orcid.org/0000-0001-8089-7150)
- Kevin D. Hall (ORCID: https://orcid.org/0000-0003-4062-3133)
- Erikka Loftfield (ORCID: https://orcid.org/0000-0002-3573-8748)
- Charles Edwards Matthews (ORCID: https://orcid.org/0000-0001-8037-3103)
- Kirsten Herrick (ORCID: https://orcid.org/0000-0001-8646-599X)
- Lauren E O’Connor (ORCID: https://orcid.org/0000-0002-4142-5756)
- Rashmi R. Sinha (ORCID: https://orcid.org/0000-0002-2466-7462)
- Neal D. Freedman (ORCID: https://orcid.org/0000-0003-0074-1098)
- Steven C. Moore (ORCID: https://orcid.org/0000-0002-8169-1661)
- Sang‐Kyu Lee (ORCID: https://orcid.org/0000-0001-6714-850X)
Institutions
- Universidade de São Paulo (BR)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Departamento de Epidemiología (GT)
- Information Management Services (US)
- Department of Physiological Sciences (RU)
- National Cancer Institute (US)
- Cancer Genetics (United States) (US)
- Center for Cancer Research (US)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1371/journal.pmed.1004560
- Citations
- 10
- Primary Topic
- Consumer Attitudes and Food Labeling
- Type
- article
- Field-Weighted Citation Impact
- 18.79
Funders
- Fundação de Amparo à Pesquisa do Estado da Bahia
- Division of Cancer Epidemiology and Genetics, National Cancer Institute