Higher Circulating Alpha-klotho Levels Increase All-cause Mortality Through Mediation Effects of Liver Fibrosis: A Second Analysis of National Health and Nutrition Examination Survey
This study verified a U-shaped association between α-klotho and all-cause mortality in the U.S. general population. Moreover, higher α-klotho levels were associated with an increased risk of death, partially due to liver fibrosis mediating this association.
Authors
- Kai Wei (ORCID: https://orcid.org/0000-0001-7984-1758)
- Yanping Yang (ORCID: https://orcid.org/0000-0002-5102-3996)
- Xinhua Luo (ORCID: https://orcid.org/0000-0001-8285-3063)
- Chun Chen (ORCID: https://orcid.org/0000-0002-3608-6972)
- Qing Zhang (ORCID: https://orcid.org/0000-0003-4666-2547)
- Libin Wang (ORCID: https://orcid.org/0000-0002-7861-1560)
- Mengmeng Chen (ORCID: https://orcid.org/0000-0003-3768-9713)
- Qi Chen (ORCID: https://orcid.org/0000-0002-3759-5816)
- Shuimei Sun
Institutions
- Guizhou Provincial People's Hospital (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- The Journals of Gerontology Series A
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1093/gerona/glaf109
- Citations
- 3
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.29