Modification of the microstructure of the CERN- CLEAR-VHEE beam at the picosecond scale modifies ZFE morphogenesis but has no impact on hydrogen peroxide production
Our findings suggest that scanning strategies employing high intensity beamlets may be optimal for the clinical implementation of FLASH radiotherapy. These insights are pivotal for guiding the development of future FLASH protocols in radiation oncology.
Authors
- Marie‐Catherine Vozenin (ORCID: https://orcid.org/0000-0002-2109-8073)
- Adrien Martinotti
- Pierre Korysko (ORCID: https://orcid.org/0000-0002-7878-2298)
- Billy W. Loo (ORCID: https://orcid.org/0000-0002-2521-0544)
- R. Corsini (ORCID: https://orcid.org/0000-0002-0934-8199)
- Pelagia Tsoutsou (ORCID: https://orcid.org/0000-0002-6490-9278)
- Manjit Dosanjh (ORCID: https://orcid.org/0000-0003-1378-349X)
- Vilde Rieker (ORCID: https://orcid.org/0000-0002-7449-3595)
- Houda Kacem
- Gérard Baldacchino (ORCID: https://orcid.org/0000-0002-4126-6003)
- Jonathan Ollivier
- Joseph J. Bateman
- Charles L. Limoli (ORCID: https://orcid.org/0000-0002-1321-4142)
- Wilfrid Farabolini
- Louis Kunz
Institutions
- University of California, Irvine (US)
- European Organization for Nuclear Research (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1016/j.radonc.2025.110942
- Citations
- 8
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 12.15
Funders
- National Science Foundation
- Foundation for the National Institutes of Health
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Krebsliga Schweiz
- Université de Lausanne
- Swiss Cancer Research Foundation
- National Institutes of Health