Synthesis of homocarnosine for applications in bioactive peptide and functional food studies
Homocarnosine is a brain-specific dipeptide composed of γ-aminobutyric acid and L-histidine. In contrast to its well-known analog carnosine, homocarnosine is under-explored and noncommercially available. Here, we report an in-house and practical procedure for solid-phase synthesis of homocarnosine, yielding a purity of >95%. Applications of the synthesized homocarnosine in in vitro assays exhibited antioxidant and muscle-fiber-cell viability activities.
Authors
- Makoto Hirayama (ORCID: https://orcid.org/0000-0002-8419-0352)
- Ruge Cao (ORCID: https://orcid.org/0000-0002-7355-6240)
- Thanutchaporn Kumrungsee (ORCID: https://orcid.org/0000-0002-6196-5186)
- Hisato Kuniyoshi (ORCID: https://orcid.org/0000-0003-2955-8043)
- Sudathip Sae‐tan (ORCID: https://orcid.org/0000-0002-6960-0296)
- Tomoka Nagao
- Takeshi Arima (ORCID: https://orcid.org/0000-0003-1006-4430)
- Kanako Sato (ORCID: https://orcid.org/0000-0003-4863-0004)
- Akiko Koi
- Takumi Komaru
- Masubon Thongngam
- Yoshiaki Nakamura (ORCID: https://orcid.org/0000-0002-6711-2424)
- Jun‐ichi Kakimura
- Noriyuki Yanaka
- Hitoshi Fujitaka
Institutions
- Hiroshima University (JP)
- Tianjin University of Science and Technology (CN)
- Kasetsart University (TH)
Publication Details
- Journal
- Bioscience Biotechnology and Biochemistry
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1093/bbb/zbaf075
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 0.00