Dual Difficulty-Aware Adaptive Pseudo Labeling for Semi-Supervised CNV Segmentation

In clinical practice, obtaining a large amount of labeled CNV data is very difficult. Semi-supervised learning can effectively utilize a large amount of unlabeled CNV data. Since CNV has complex features such as blurred and unevenly distributed pixels on the edges, there are differences in the segmentation difficulty between pixels in the same image. Existing semi-supervised segmentation methods do not consider the segmentation difficulty of pixels, which will reduce the segmentation accuracy. To address this problem, we propose a dual difficulty-aware adaptive pseudo-label learning (D2APL) method for semi-supervised CNV segmentation. The proposed dual difficulty awareness includes segmentation difficulty perception of pixels in labeled and unlabeled data. For labeled data, we propose a classification confidence-guided difficulty perception method. For unlabeled data, we propose a model stability-guided difficulty perception method. Finally, we propose a difficulty-aware self-training method to dynamically adjust the threshold of pseudolabels according to the difficulty, thereby improving the utilization of difficult-to-segment pixels in unlabeled data. Experimental results show that our method outperforms the state-of-the-art method in CNV segmentation.