Genotypic analysis of drug-resistant tuberculosis in Ghana: Insights into pre-XDR and XDR-TB
The predominant mutations associated with pre-XDR-TB were D94A and C1402T for fluoroquinolone and aminoglycosides resistance respectively. The proportion of pre-XDR-TB among MDR-TB patients in Ghana was 7.4%; however, no XDR-TB was detected. A sustained surveillance of pre-XDR-TB and XDR-TB is recommended.
Authors
- Roger Laryea
- Stephen Ofori Yirenkyi (ORCID: https://orcid.org/0000-0002-6106-3430)
- Osmanu Taufik
- Japheth A. Opintan (ORCID: https://orcid.org/0000-0003-3928-2116)
- Gloria Ivy Mensah (ORCID: https://orcid.org/0000-0002-6499-5946)
- Amanquador Acquah-Keelson
Institutions
- University of Ghana (GH)
- University of Health and Allied Sciences (GH)
- All Nations University (GH)
- Noguchi Memorial Institute for Medical Research (GH)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1371/journal.pone.0323527
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00