Analysis of clinical audiological characteristics in children with Williams syndrome in China
This study revealed that children with WS frequently exhibit middle and inner ear dysfunction, often accompanied by HL or subclinical cochlear impairment, which can emerge before age 3. Prolonged ABR latency indicates delayed auditory nerve myelination, while shortened interpeak latency III-V may serve as an electrophysiological marker in this population. Long-term, regular hearing follow-up is recommended to enable early HL detection and timely treatment of contributing conditions.
Authors
- Junxia Guo (ORCID: https://orcid.org/0009-0005-0569-2522)
- Bin Xu (ORCID: https://orcid.org/0000-0001-9922-0609)
- Jiyang Shen
- Fangfang Li (ORCID: https://orcid.org/0000-0003-2404-799X)
- Dan Yao (ORCID: https://orcid.org/0000-0002-9629-6381)
- Jie Shao (ORCID: https://orcid.org/0000-0001-5873-7230)
- Weijun Chen (ORCID: https://orcid.org/0000-0001-8927-9738)
- Chai Ji
Institutions
- Children's Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Orphanet Journal of Rare Diseases
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1186/s13023-025-03650-2
- Primary Topic
- Williams Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00