ROBIN: A unified nanopore-based assay integrating intraoperative methylome classification and next-day comprehensive profiling for ultra-rapid tumor diagnosis
Nanopore sequencing can greatly improve turnaround times for standard-of-care diagnostic testing and is furthermore able to reliably provide clinically actionable intraoperative tumor classification.
Authors
- Dan C. Martin (ORCID: https://orcid.org/0000-0002-1904-1449)
- Satrio Wibowo (ORCID: https://orcid.org/0000-0002-8892-3808)
- Simon Deacon
- Nadine Holmes (ORCID: https://orcid.org/0000-0001-7470-3786)
- Hannah D. Mason (ORCID: https://orcid.org/0000-0003-1701-4655)
- Rory Munro (ORCID: https://orcid.org/0000-0003-3158-0303)
- Simon Paine (ORCID: https://orcid.org/0000-0002-1434-3931)
- Inswasti Cahyani (ORCID: https://orcid.org/0000-0002-1171-3255)
- Graeme Fox (ORCID: https://orcid.org/0000-0001-7980-6944)
- Felix Sahm (ORCID: https://orcid.org/0000-0001-5441-1962)
- Robert Goldspring
- Matthew Loose (ORCID: https://orcid.org/0000-0002-5264-0929)
- Stuart Smith (ORCID: https://orcid.org/0000-0002-4556-2707)
- Thomas S. Murray (ORCID: https://orcid.org/0000-0002-6829-7213)
- Areeba Patel (ORCID: https://orcid.org/0000-0003-0374-4227)
- Mark Housley
- Sebastian Brandner (ORCID: https://orcid.org/0000-0002-8635-7195)
- A. Sharif (ORCID: https://orcid.org/0009-0006-8897-0360)
Institutions
- Nottingham University Hospitals NHS Trust (GB)
- University College London Hospitals NHS Foundation Trust (GB)
- University of Nottingham (GB)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-04-07
- DOI
- https://doi.org/10.1093/neuonc/noaf103
- Citations
- 10
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 16.25
Funders
- Wellcome Trust
- British Neuropathological Society
- Pathological Society of Great Britain and Ireland
- Jean Shanks Foundation