Integrative Immune Signature of Complementary Circulating and Tumoral Biomarkers Maximizes the Predictive Power of Adjuvant Immunotherapeutic Benefits in High-risk Melanoma
Integrating candidate blood and tumor immune-related biomarkers generated a baseline signature that maximizes the prediction of immunotherapeutic benefits in reference to the compartmental biomarker signatures.
Authors
- Dung‐Tsa Chen (ORCID: https://orcid.org/0000-0001-5026-415X)
- John M. Kirkwood (ORCID: https://orcid.org/0000-0002-3570-4476)
- Issam El Naqa (ORCID: https://orcid.org/0000-0001-6023-1132)
- Arivarasan Karunamurthy (ORCID: https://orcid.org/0000-0002-5739-4923)
- Ahmad A. Tarhini (ORCID: https://orcid.org/0000-0002-3193-9702)
- Lisa H. Butterfield (ORCID: https://orcid.org/0000-0002-3439-9844)
- Timothy I. Shaw (ORCID: https://orcid.org/0000-0002-9316-1924)
- Patrick Hwu (ORCID: https://orcid.org/0000-0002-8293-1313)
- Alyssa Obermayer (ORCID: https://orcid.org/0000-0002-7333-973X)
- Sandra J. Lee (ORCID: https://orcid.org/0000-0002-8626-639X)
- Vernon K. Sondak (ORCID: https://orcid.org/0000-0003-1090-484X)
- William A. LaFramboise (ORCID: https://orcid.org/0000-0002-6024-810X)
- Islam Eljilany (ORCID: https://orcid.org/0000-0001-6387-5419)
- Walter J. Storkus (ORCID: https://orcid.org/0000-0001-8961-4444)
- F. Stephen Hodi (ORCID: https://orcid.org/0000-0001-6825-091X)
- HOWARD Z. STREICHER (ORCID: https://orcid.org/0000-0003-3683-9804)
Institutions
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Allegheny Health Network (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- Moffitt Cancer Center (US)
- Applied Science Laboratories (United States) (US)
- Dana-Farber Cancer Institute (US)
- UPMC Hillman Cancer Center (US)
- National Cancer Institute (MY)
- University of Pittsburgh Medical Center (US)
- National Cancer Institute (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3980
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- University of Pittsburgh
- Moffitt Cancer Center