Identification and validation of interferon-driven gene signature as a predictor of response to methotrexate in juvenile idiopathic arthritis
In children with JIA, a high IFN-driven gene signature is associated with a better response to MTX than those with a low IFN-driven gene signature. These data could pave the way to clinically validated tools to identify those most likely to require medications in addition to MTX to control inflammation.
Authors
- Claire T. Deakin (ORCID: https://orcid.org/0000-0002-7044-5801)
- Chris Wallace (ORCID: https://orcid.org/0000-0001-9755-1703)
- Melissa Kartawinata (ORCID: https://orcid.org/0000-0002-9432-393X)
- Elizabeth C. Rosser (ORCID: https://orcid.org/0000-0003-4800-4695)
- Lucy R. Wedderburn (ORCID: https://orcid.org/0000-0002-7495-1429)
- Elizabeth Ralph (ORCID: https://orcid.org/0000-0002-7955-7084)
- Restuadi Restuadi (ORCID: https://orcid.org/0000-0001-8434-4465)
- Beth Jebson
- Wei‐Yu Lin (ORCID: https://orcid.org/0000-0002-9267-7988)
- Emma J Welsh
- Kathryn O’Brien
Institutions
- University College Hospital (GB)
- University of Cambridge (GB)
- Great Ormond Street Hospital (GB)
- National Institute for Health and Care Research (GB)
- MRC Biostatistics Unit (GB)
- University College London (GB)
- Medical Research Council (GB)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1016/j.ard.2025.03.007
- Citations
- 3
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 5.31
Funders
- Cincinnati Children's Hospital Medical Center
- Wellcome Trust
- Kennedy Trust for Rheumatology Research
- Sparks
- Great Ormond Street Hospital Charity
- Versus Arthritis
- Medical Research Council
- NIHR Cambridge Biomedical Research Centre
- NIHR Great Ormond Street Hospital Biomedical Research Centre
- National Institute of Arthritis and Musculoskeletal and Skin Diseases