Pragmatic preoperative molecular classification of endometrial cancers; Replacing POLE sequencing with hormone receptor staining
Preoperative evaluation of ER, PR, MMR and p53 identifies four molecular and prognostic groups. This pragmatic classification allows POLE sequencing to be omitted. Our proposed algorithm saves time and resources and is a valuable alternative to full molecular classification.
Authors
- Hilde E. Lien (ORCID: https://orcid.org/0000-0001-7814-9786)
- Jone Trovik (ORCID: https://orcid.org/0000-0002-3808-6407)
- Kathrine Woie
- Camilla Krakstad (ORCID: https://orcid.org/0000-0002-0174-8139)
- Ingfrid S. Haldorsen (ORCID: https://orcid.org/0000-0001-9313-7564)
- Marta E. Hjelmeland
- Mari K. Halle (ORCID: https://orcid.org/0000-0002-2660-8271)
- Hege F. Berg (ORCID: https://orcid.org/0000-0002-1712-6609)
Institutions
- Haukeland University Hospital (NO)
- University of Bergen (NO)
Publication Details
- Journal
- Gynecologic Oncology
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1016/j.ygyno.2025.05.005
- Citations
- 4
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.23
Funders
- Universitetet i Bergen
- Norges Forskningsråd