TSPAN15 enhances EMT-mediated metastasis of HCC by promoting autophagy through BTRC-mediated PDCD4 degradation
Abnormally expressed TSPAN15 promotes the degradation of tumor suppressor gene PDCD4 through ubiquitination, thereby promoting autophagy and autophagy-mediated EMT and metastasis of HCC cells, demonstrating the importance of TSPAN15 in the molecular etiology of HCC and its potential therapeutic value.
Authors
- Qingya Hao (ORCID: https://orcid.org/0000-0002-4205-2242)
- Jie Chen (ORCID: https://orcid.org/0009-0002-1536-2007)
- Yuhua Lü (ORCID: https://orcid.org/0000-0002-8016-8430)
- Zicheng Shao
Institutions
- Nantong University (CN)
- Soochow University (CN)
- Affiliated Hospital of Nantong University (CN)
- Second Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Molecular Immunology
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1016/j.molimm.2025.05.012
- Citations
- 1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.35