Mycophenolate Mofetil for Steroid-Refractory Immune-Related Hepatitis and Sclerosing Cholangitis Following Neoadjuvant Chemoimmunotherapy in Non-Small Cell Lung Cancer: A Case Report

This case highlights the potential role of mycophenolate mofetil in managing steroid-refractory immune-related liver injury induced by neoadjuvant chemoimmunotherapy in non-small cell lung cancer. Although immunosuppressive therapy may enable definitive surgery, it may also contribute to tumor regrowth and serious postoperative complications. As the use of neoadjuvant chemoimmunotherapy expands, further clinical experience is needed to guide the management of immune-related adverse events and ensure safe and effective surgical outcomes.

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Publication Details

Journal
Surgical Case Reports
Published
2025-01-01
DOI
https://doi.org/10.70352/scrj.cr.25-0192
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
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article

Mycophenolate Mofetil for Steroid-Refractory Immune-Related Hepatitis and Sclerosing Cholangitis Following Neoadjuvant Chemoimmunotherapy in Non-Small Cell Lung Cancer: A Case Report

Yoshimitsu Hirai, Hideto Iguchi, Daiki Kitahara, Kuninobu Kanai et al.
Surgical Case Reports
Cancer Immunotherapy and Biomarkers
article

Mycophenolate Mofetil for Steroid-Refractory Immune-Related Hepatitis and Sclerosing Cholangitis Following Neoadjuvant Chemoimmunotherapy in Non-Small Cell Lung Cancer: A Case Report

Yoshimitsu Hirai, Hideto Iguchi, Daiki Kitahara, Kuninobu Kanai, Yuhei Harutani, Takahiro Kaki, Issei Hirai
article en

Abstract

This case highlights the potential role of mycophenolate mofetil in managing steroid-refractory immune-related liver injury induced by neoadjuvant chemoimmunotherapy in non-small cell lung cancer. Although immunosuppressive therapy may enable definitive surgery, it may also contribute to tumor regrowth and serious postoperative complications. As the use of neoadjuvant chemoimmunotherapy expands, further clinical experience is needed to guide the management of immune-related adverse events and ensure safe and effective surgical outcomes.

Surgical Case ReportsVol. 11(1)
Wakayama Medical University (JP), Naga Municipal Hospital (JP)
Good health and well-being
Openalex Percentile: Top 83%
Cancer Immunotherapy and Biomarkers
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Mycophenolate Mofetil for Steroid-Refractory Immune-Related Hepatitis and Sclerosing Cholangitis Following Neoadjuvant Chemoimmunotherapy in Non-Small Cell Lung Cancer: A Case Report — Yoshimitsu Hirai, Hideto Iguchi, et al. · Surgical Case Reports (2025) | TGRS Research Map | TGRS