Mycophenolate Mofetil for Steroid-Refractory Immune-Related Hepatitis and Sclerosing Cholangitis Following Neoadjuvant Chemoimmunotherapy in Non-Small Cell Lung Cancer: A Case Report
This case highlights the potential role of mycophenolate mofetil in managing steroid-refractory immune-related liver injury induced by neoadjuvant chemoimmunotherapy in non-small cell lung cancer. Although immunosuppressive therapy may enable definitive surgery, it may also contribute to tumor regrowth and serious postoperative complications. As the use of neoadjuvant chemoimmunotherapy expands, further clinical experience is needed to guide the management of immune-related adverse events and ensure safe and effective surgical outcomes.
Authors
- Yoshimitsu Hirai (ORCID: https://orcid.org/0000-0001-7428-9618)
- Hideto Iguchi (ORCID: https://orcid.org/0000-0002-9643-1475)
- Daiki Kitahara
- Kuninobu Kanai
- Yuhei Harutani
- Takahiro Kaki
- Issei Hirai
Institutions
- Wakayama Medical University (JP)
- Naga Municipal Hospital (JP)
Publication Details
- Journal
- Surgical Case Reports
- Published
- 2025-01-01
- DOI
- https://doi.org/10.70352/scrj.cr.25-0192
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00