Chemical Constituents of Deep‐Sea Derived Fungus <i>Pseudogymnoascus hyalinus</i> and Their Ferroptosis Inhibitory Activity
Four new polyketides including one indanone (1), one isobenzofuranone (2), and two naphthoquinones (3 and 4) were isolated from the deep-sea-derived fungus Pseudogymnoascus hyalinus, along with 20 known compounds (5-24). The structures of new compounds were established by comprehensive analyses of their 1D and 2D NMR, HRESIMS, as well as TD-DFT-ECD. Compounds 5, 6, and 10 displayed potent inhibitory effects against RSL3 induced ferroptosis with EC<sub>50</sub> values of 4.74, 1.55, and 3.72 µM, respectively.
Authors
- Xian‐Wen Yang (ORCID: https://orcid.org/0000-0002-4967-0844)
- Zheng‐Biao Zou (ORCID: https://orcid.org/0009-0001-8824-7272)
- Tian‐Hua Zhong (ORCID: https://orcid.org/0009-0002-0342-6253)
- Yan Li (ORCID: https://orcid.org/0009-0009-7839-1885)
- You Li (ORCID: https://orcid.org/0000-0002-8506-8439)
- Chun‐Lan Xie (ORCID: https://orcid.org/0009-0007-2518-9355)
- Lisheng Li (ORCID: https://orcid.org/0000-0002-0793-272X)
Institutions
- Fujian Medical University (CN)
- Ministry of Natural Resources (CN)
- Fujian Institute of Oceanography (CN)
- Shanghai Ocean University (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1002/cbdv.202501289
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00