Mitochondrial calcium homeostasis mediated by estradiol contributes to atrial fibrillation protection
We reveal that estradiol modulates MCU-mediated mitochondrial calcium homeostasis to ameliorate AF-related cellular phenotypes in vitro, implicating the estrogen-MCU axis as a promising intervention target, though its in vivo cardioprotective effects demand additional investigation. Estrogen deficiency disrupts this axis, triggering maladaptive upregulation of MICU1/NCX/LETM1 and calcium-driven remodeling. Targeting ERβ-MCU signaling may offer novel therapeutic strategies for AF, particularly in hypoestrogenic states such as menopause.
Authors
- Guizhou Ma (ORCID: https://orcid.org/0000-0002-4088-6761)
- Bingying Huang (ORCID: https://orcid.org/0000-0003-2990-1622)
- Bing Lu (ORCID: https://orcid.org/0009-0002-8700-9632)
- Ying Wang (ORCID: https://orcid.org/0000-0002-5407-2443)
Institutions
- Shantou Central Hospital (CN)
Publication Details
- Journal
- Biochemical and Biophysical Research Communications
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1016/j.bbrc.2025.152050
- Citations
- 4
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 5.55