Efficacy and Safety of Enalapril and Propranolol on Neurologic Recovery After Isolated Severe Traumatic Brain Injury: A Randomized Clinical Trial
Regarding neurologic recovery and other outcomes, enalapril and propranolol, both alone and in combination, are effective and safe after severe isolated TBI. Considering long-term outcomes, propranolol showed more promising results in GOS-E during the follow-up period.
Authors
- Mohammad Sharafi (ORCID: https://orcid.org/0000-0002-8469-5625)
- Donya Sheibani Tehrani (ORCID: https://orcid.org/0000-0002-5893-0353)
- Sadegh Baradaran Mahdavi (ORCID: https://orcid.org/0000-0002-1956-1372)
- Mina Foroughi (ORCID: https://orcid.org/0000-0001-6640-7493)
- Mehdi Mahmoodkhani (ORCID: https://orcid.org/0000-0001-6903-0839)
- Christian A. Bowers (ORCID: https://orcid.org/0000-0001-6299-503X)
- Ahmad Sahraei
- Arman Sourani (ORCID: https://orcid.org/0000-0002-8998-9446)
- Shaahin Veisi (ORCID: https://orcid.org/0000-0001-5807-9872)
- Roham Nik Khah (ORCID: https://orcid.org/0000-0001-6566-0526)
- Mehdi Shafiei
Institutions
- Isfahan University of Medical Sciences (IR)
- Hurley Medical Center (US)
Publication Details
- Journal
- World Neurosurgery
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1016/j.wneu.2025.124078
- Citations
- 1
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 1.39