HMG Box-containing Protein 1 (HBP1) Protects Against Pancreatic Injury in Acute Pancreatitis but Promotes Neoplastic Progression
HBP1 upregulation in pancreatitis mitigates pancreatic inflammatory injury; however, in the presence of oncogenic KRAS, it facilitates PanIN progression. Thus, HBP1 serves as a critical regulator in both pancreatitis and early pancreatic neoplasia, representing a potential therapeutic target for intervening pancreatitis and PanIN progression.
Authors
- Terry K. Morgan (ORCID: https://orcid.org/0000-0003-0742-5012)
- Shangyuan Ye (ORCID: https://orcid.org/0000-0002-7504-8215)
- Koei Chin (ORCID: https://orcid.org/0000-0001-8061-7462)
- Dove Keith
- Stuart P. Weisberg (ORCID: https://orcid.org/0000-0002-8698-5976)
- John Muschler (ORCID: https://orcid.org/0000-0001-9916-5937)
- Dmytro Grygoryev
- Taelor Ekstrom (ORCID: https://orcid.org/0000-0001-9829-9570)
- Rosalie C. Sears (ORCID: https://orcid.org/0000-0003-1558-2413)
- Syber Haverlack
- Vidhi M. Shah (ORCID: https://orcid.org/0000-0001-7934-978X)
- Elise C. Manalo (ORCID: https://orcid.org/0000-0003-2752-5280)
- Seung-Won Lee (ORCID: https://orcid.org/0000-0001-8893-8332)
- Jinho Lee (ORCID: https://orcid.org/0000-0003-1330-3687)
- Ju Young Lee (ORCID: https://orcid.org/0000-0001-7548-2284)
- Jung-Sun Kim (ORCID: https://orcid.org/0000-0003-2454-8065)
- Mark Berry (ORCID: https://orcid.org/0000-0002-8534-2012)
- Małgorzata Szczepaniak
- Carlos Origel Marmolejo
Institutions
- Oregon Health & Science University (US)
- Columbia University Irving Medical Center (US)
- Oregon Medical Research Center (US)
- Pancreatic Cancer UK (GB)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101536
- Citations
- 1
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- National Pancreas Foundation
- School of Medicine, Oregon Health and Science University
- National Cancer Institute
- Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health and Science University