Deuterated Oxazoloisoindolinones via Photocatalytic Deoxygenative Cyclization of Amino Acid Derivatives
Abstract A stereoselective synthesis of deuterated oxazoloisoindolinones using D2O was achieved through photocatalytic deoxygenation of readily available N-phthalimide amino acids, followed by an intramolecular 5-endo-trig cyclization. This protocol provides an efficient access to a broad array of deuterium-labeled N,O-heterobicycles with excellent deuterium incorporation.
Authors
- Yan Geng (ORCID: https://orcid.org/0000-0002-5186-340X)
- Hanlin Yang (ORCID: https://orcid.org/0000-0001-8845-4805)
- Songjie Yu (ORCID: https://orcid.org/0000-0001-9156-8774)
- Changqing Wei (ORCID: https://orcid.org/0000-0002-3743-7279)
- Yue Ma (ORCID: https://orcid.org/0000-0002-8619-8614)
Institutions
- Shandong University (CN)
- Dalian University of Technology (CN)
- University of Jinan (CN)
Publication Details
- Journal
- Synlett
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1055/a-2616-5579
- Primary Topic
- Synthesis and pharmacology of benzodiazepine derivatives
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China