Design, Synthesis, and Antifungal Activity of Isochroman-Fused Coumarins against Rhizoctonia solani

Abstract This study presents the synthesis and antifungal assessment of novel isochroman-fused coumarin derivatives against Rhizoctonia solani. The compounds were synthesized using an efficient and environmentally benign approach and demonstrated strong in silico binding affinity to CYP51. In vitro assays further confirmed their antifungal activity, with one compound exhibiting the highest potency, achieving an ED50 value of 3.59 μM. These findings underscore the potential of isochroman-fused coumarins as eco-friendly rice sheath blight control agents.