Effect of Pu-erh tea compound solid beverage on weight loss of high-fat diet mice

Obesity is prevalent worldwide and seriously affects human health. At present, there are many reports on the lipid-lowering and weight loss effect of Pu-erh tea water extract, catechin, and theanine, but there are few studies on the synergistic lipid-lowering and weight loss of the three as a combined formula. The purpose of this study was to explore the anti-obesity effect of Pu-erh tea compound solid beverage composed of Pu-erh tea water extract, catechin, and theanine on high-fat diet mice. In this study, C57BL/6J mice were induced using a high-fat diet to construct an obesity model, and Pu-erh tea solid beverage was given by intragastric intervention. After 8 weeks of intragastric administration, the body weight, serum TG, TC, LDL-C, and liver TG and TC levels in the solid beverage intervention group were significantly decreased. The expression levels of tight junction proteins ZO-1, Occludin, and Claudin-1 in colon tissue were significantly increased. 16S rRNA analysis showed that Pu-erh tea solid beverage delayed the increase of <italic>Blautia, Helicobacter, Colidextribacter</italic> abundance, and the decrease of <italic>Akkermansia, Bacteroides, Alistipes, Faecalibaculum, Lachnospiraceae_NK4A136_group, Odoribacter</italic> abundance caused by a high-fat diet, and increased the species abundance of the intestinal microbial community. The above results showed that Pu-erh tea solid beverage could inhibit obesity in high-fat diet mice by alleviating dyslipidemia, intestinal barrier damage, and intestinal flora disorders in high-fat diet-fed mice.