Metastatic renal cell carcinoma: Synchronous vs. metachronous metastatic disease and its impact on cancer control in the IO-combination era—Real world experiences from a multi-institutional cohort
This study examined the impact of when metastases occur on survival outcomes in kidney cancer patients treated with first-line immune-combination therapies. The findings show that a longer interval before the development of metastases is associated with better outcomes.
Authors
- Alexander Cox (ORCID: https://orcid.org/0000-0001-7837-5740)
- Charis Kalogirou (ORCID: https://orcid.org/0000-0003-3802-940X)
- Friedemann Zengerling (ORCID: https://orcid.org/0000-0002-6150-2675)
- Oliver Hãhn (ORCID: https://orcid.org/0000-0001-9015-4545)
- Luka Flegar (ORCID: https://orcid.org/0000-0002-1477-9161)
- Jonathan Vollemaere
- Jörg Ellinger (ORCID: https://orcid.org/0000-0002-7526-0857)
- Marcus Sondermann (ORCID: https://orcid.org/0000-0002-4629-0707)
- Philipp Schmucker (ORCID: https://orcid.org/0000-0002-3487-0560)
- Séverine Banek
- Philip Zeuschner (ORCID: https://orcid.org/0000-0001-8898-6588)
- Angelika Mattigk (ORCID: https://orcid.org/0000-0001-8710-458X)
- Cristina Cano Garcia (ORCID: https://orcid.org/0000-0002-4829-0241)
- Niklas Klümper (ORCID: https://orcid.org/0000-0002-3258-0586)
- Johannes Huber (ORCID: https://orcid.org/0000-0001-7243-8958)
- Benedikt Hoeh (ORCID: https://orcid.org/0000-0002-4238-6584)
- Kati Erdmann (ORCID: https://orcid.org/0000-0003-3717-3637)
Institutions
- Goethe University Frankfurt (DE)
- Philipps University of Marburg (DE)
- University of Würzburg (DE)
- University Hospital Bonn (DE)
- University Medical Center Freiburg (DE)
- University Hospital Frankfurt (DE)
- University Hospital Ulm (DE)
- University Hospital Carl Gustav Carus (DE)
- Technische Universität Dresden (DE)
- Saarland University (DE)
Publication Details
- Journal
- Urologic Oncology Seminars and Original Investigations
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1016/j.urolonc.2025.04.004
- Citations
- 1
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52