Investigating Anti-Tumor Effects of Irisin in Cervical Cancer Cells: Cell Viability, Migration, and Tumor-Associated Macrophage Polarization

Irisin exhibits potent anti-cancer effects on cervical cancer cells by modulating several key cellular processes and altering the tumor microenvironment. Irisin effectively inhibits the proliferation, invasion, and migration of cervical cancer cells and affects the levels of autophagy and apoptosis. Furthermore, it inhibits cancer cells by affecting the polarization of tumor-associated macrophages, underscoring their potential as a novel therapeutic target for treating cervical cancer.

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Publication Details

Journal
Discovery Medicine
Published
2025-01-01
DOI
https://doi.org/10.24976/discov.med.202537196.84
Primary Topic
Adipose Tissue and Metabolism
Type
article
Field-Weighted Citation Impact
0.00
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article

Investigating Anti-Tumor Effects of Irisin in Cervical Cancer Cells: Cell Viability, Migration, and Tumor-Associated Macrophage Polarization

Xiaojie Ma, Guangwen Cao, Wei Yan
Discovery Medicine
Adipose Tissue and Metabolism
article

Investigating Anti-Tumor Effects of Irisin in Cervical Cancer Cells: Cell Viability, Migration, and Tumor-Associated Macrophage Polarization

Xiaojie Ma, Guangwen Cao, Wei Yan
article en

Abstract

Irisin exhibits potent anti-cancer effects on cervical cancer cells by modulating several key cellular processes and altering the tumor microenvironment. Irisin effectively inhibits the proliferation, invasion, and migration of cervical cancer cells and affects the levels of autophagy and apoptosis. Furthermore, it inhibits cancer cells by affecting the polarization of tumor-associated macrophages, underscoring their potential as a novel therapeutic target for treating cervical cancer.

Discovery MedicineVol. 37(196)
Jiangxi Pingxiang People's Hospital (CN)
Openalex Percentile: Top 85%
Adipose Tissue and Metabolism
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