Research Progress in the Cardiovascular Disease field Involving Irisin

Abstract Fibronectin type III Domain-containing 5 (FNDC5) is a precursor of Irisin. In skeletal muscle, the transcriptional coactivator PPAR-γ Coactivator-1α (PGC1-α) stimulates FNDC5 expression through biological reactions. FNDC5 is a membrane protein that is cleaved and secreted as irisin, a newly identified hormone. Irisin plays a critical role in modulating body metabolism, thermogenesis, and oxidative stress reduction. In recent years, studies on Irisin have increasingly emerged in the rapidly advancing field of cardiovascular diseases. This review summarizes recent findings on the correlation between irisin and cardiovascular diseases (such as lipid metabolism, acute myocardial infarction, heart failure, myocardial remodeling, blood pressure regulation and biomarkers, etc.), and outlines future research directions.