A fully automated, high-throughput electro-extraction and analysis workflow for acylcarnitines in human plasma and mouse muscle tissues
This study provides an automated, high-throughput, and cost-effective workflow enabling extraction and analysis of 120 samples per day, with a cost of <0.1 Euro per sample. It presents a significant stride towards the creation of fully-automated, high-throughput bioanalysis workflows for large-scale studies involving biomass limited samples in the foreseeable future.
Authors
- Renata M. C. Brandt (ORCID: https://orcid.org/0000-0003-0514-5623)
- Yvonne Rijksen
- Bert Wouters (ORCID: https://orcid.org/0000-0001-7362-3987)
- Amy C. Harms (ORCID: https://orcid.org/0000-0002-2931-4295)
- Yupeng He (ORCID: https://orcid.org/0000-0002-3453-9499)
- Wilbert P. Vermeij (ORCID: https://orcid.org/0000-0002-9690-1385)
- Paul Miggiels (ORCID: https://orcid.org/0000-0001-8714-3968)
- Thomas Hankemeier (ORCID: https://orcid.org/0000-0001-7871-2073)
Institutions
- Leiden University (NL)
- Netherlands Metabolomics Centre (NL)
- Princess Máxima Center (NL)
- Centre for Human Drug Research (NL)
- Erasmus MC Cancer Institute (NL)
Publication Details
- Journal
- Analytica Chimica Acta
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1016/j.aca.2025.344224
- Citations
- 1
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Universiteit Leiden
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek