Enhancing translational research in metastatic cancer through an open science environment: The UPTIDER experience
Translational research in metastatic cancer is hindered by the scarcity of metastatic tumor samples.Postmortem tissue donation programs, such as UPTIDER (NCT04531696), address this issue by allowing comprehensive collection of metastatic tissue samples.The success of these programs involves a robust open science environment (OSE) that ensures multidisciplinary collaboration, research quality, and GDPR and FAIR compliance.While open science is often reduced to data availability upon publication, here we demonstrate the importance of developing upstream phases by presenting the UPTIDER OSE.It contains (i) an electronic case report form (eCRF) to capture over 750 clinical features, including treatment lines and metastases, (ii) a laboratory information management system (LIMS) to track metadata using over 100 sample features from logistical to anatomical information, (iii) a distributed version control system for code tracking, (iv) a storage
Authors
- Ha-Linh Nguyen (ORCID: https://orcid.org/0000-0002-2538-7657)
- Patrick Neven (ORCID: https://orcid.org/0000-0002-1434-9460)
- Hava Izci (ORCID: https://orcid.org/0000-0002-3344-0198)
- Kristien Borremans (ORCID: https://orcid.org/0000-0001-7047-1543)
- F. Richard (ORCID: https://orcid.org/0000-0003-4757-7029)
- Marion Maetens (ORCID: https://orcid.org/0000-0002-0505-2622)
- Anirudh Pabba (ORCID: https://orcid.org/0000-0003-2002-6956)
- Amena Mahdami (ORCID: https://orcid.org/0000-0002-3226-6933)
- Josephine Van Cauwenberge (ORCID: https://orcid.org/0000-0001-9802-186X)
- Madita Nysen
- Sophia Leduc (ORCID: https://orcid.org/0000-0002-4931-1999)
- Elia Mario Biganzoli (ORCID: https://orcid.org/0000-0003-1202-5873)
- Christine Desmedt (ORCID: https://orcid.org/0000-0002-5223-5579)
- Maxim De Schepper (ORCID: https://orcid.org/0000-0001-9829-8535)
- Hans Wildiers (ORCID: https://orcid.org/0000-0001-8990-7837)
- Karen Van Baelen (ORCID: https://orcid.org/0000-0002-5700-3574)
- Gitte Zels (ORCID: https://orcid.org/0000-0002-6332-3830)
- Tatjana Geukens (ORCID: https://orcid.org/0000-0001-8828-8739)
- Giuseppe Floris (ORCID: https://orcid.org/0000-0003-2391-5425)
- E. Rousseau
- Wouter Van Den Bogaert (ORCID: https://orcid.org/0000-0002-5803-3409)
- Sigrid Hatse (ORCID: https://orcid.org/0000-0002-6764-2628)
- Peter Vermuelen
- Angelica Di Tommaso
Institutions
- University of Milan (IT)
- Universitair Ziekenhuis Leuven (BE)
- KU Leuven (BE)
Publication Details
- Published
- 2025-05-20
- DOI
- https://doi.org/10.21428/1192f2f8.e0e5b5a1
- Citations
- 1
- Primary Topic
- Biomedical and Engineering Education
- Type
- article
- Field-Weighted Citation Impact
- 0.67