Genetic polymorphisms in folate metabolism and their association with recurrent spontaneous abortion
We identified a significant association between the TT genotype of MTHFR C677T and reduced red blood cell folate concentration. Additionally, the AG and GG genotypes of MTRR A66G were found to be linked to an increased risk of RSA. These findings suggest that specific variants in genes encoding folate metabolism enzymes may contribute to the risk of recurrent spontaneous abortion.
Authors
- R. Yu (ORCID: https://orcid.org/0000-0002-2060-2565)
- Aining Wu
- Ya Tuo (ORCID: https://orcid.org/0000-0001-9684-6753)
- Kyung Song (ORCID: https://orcid.org/0000-0002-9761-8733)
Institutions
- Mongolian National University (MN)
Publication Details
- Journal
- The Journal of Maternal-Fetal & Neonatal Medicine
- Published
- 2025-05-19
- DOI
- https://doi.org/10.1080/14767058.2025.2505769
- Citations
- 4
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 6.67
Funders
- Natural Science Foundation of Inner Mongolia
- Research Program of Science and Technology at Universities of Inner Mongolia Autonomous Region