Single-cell transcriptomics reveals cellular dynamics and chemokine CXCL2-mediated smooth muscle cell proliferation in arterial repair
This study provides a comprehensive cell atlas of the injured artery, offering valuable insights into the complex cellular interactions, signaling pathways and immune responses involved in orchestrating vascular repair. Our findings show chemokine CXCL2 as a key mediator of SMC proliferation and provide a roadmap for developing CXCL2-targeted therapies to improve vascular outcomes in PCI patients.
Authors
- Chao Yang (ORCID: https://orcid.org/0000-0003-1368-087X)
- Ming‐Jiun Yu (ORCID: https://orcid.org/0000-0003-0393-4696)
- Qiuli Sun
- Jinyu Huang (ORCID: https://orcid.org/0000-0003-4993-3197)
- Xingxiao Huang (ORCID: https://orcid.org/0009-0006-4560-1477)
- Xiao Liu (ORCID: https://orcid.org/0009-0008-1394-9772)
- Long Wang (ORCID: https://orcid.org/0000-0002-7067-0558)
- Ping Yan (ORCID: https://orcid.org/0000-0001-9484-990X)
Institutions
- Westlake University (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-20
- DOI
- https://doi.org/10.3389/fimmu.2025.1591557
- Citations
- 3
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- National Natural Science Foundation of China