DEHP exposure alters carcinoembryonic antigen family member transcript levels and modulates responses to activin A in the murine placenta
Despite minimal morphological changes, transcriptomic differences suggest that spongiotrophoblast cells and syncytiotrophoblast giant cells are DEHP exposure targets, with carcinoembryonic antigen family transcripts susceptible to its effects. Additionally, DEHP modulates placental gene transcript levels when activin A is unopposed in vivo.
Authors
- Kate L. Loveland (ORCID: https://orcid.org/0000-0002-5750-8046)
- Sarah C. Moody (ORCID: https://orcid.org/0000-0003-4478-142X)
- Emily J. Camm (ORCID: https://orcid.org/0000-0003-0767-2697)
- Sarah A. Marshall (ORCID: https://orcid.org/0000-0001-7276-1405)
- Lacey Klompmaker
- Constance Malliaras
- Junlan Iris
Institutions
- Hudson Institute of Medical Research (AU)
- Monash University (AU)
Publication Details
- Journal
- Placenta
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1016/j.placenta.2025.05.017
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hudson Institute of Medical Research
- National Health and Medical Research Council