Distinct Disconnection Patterns Explain Task-Specific Motor Impairment and Outcome After Stroke
In summary, our study identified distinct disconnection patterns indicative of specific aspects of motor impairment and outcome after stroke, highlighting a time- and task-dependent role of the contralesional hemisphere and suggesting a domain-general compensatory role of nonsensorimotor temporal areas. From a mechanistic perspective, differences in disconnection patterns predictive of initial motor impairment versus outcome suggest a stronger dependence of basal motor control on the brain's structural reserve during motor recovery. Our results extend our current network-level understanding of task-specific motor impairment and recovery, and emphasize the potential of connectome-based lesion-symptom mapping for future clinical applications.
Authors
- Gereon R. Fink (ORCID: https://orcid.org/0000-0002-8230-1856)
- Christian Grefkes (ORCID: https://orcid.org/0000-0002-1656-720X)
- Elizabeth Rizor (ORCID: https://orcid.org/0000-0002-5833-4471)
- Frank E. Garcea (ORCID: https://orcid.org/0000-0002-8843-9127)
- Anna R. Schönberger
- Lukas Hensel (ORCID: https://orcid.org/0000-0002-3915-5275)
- Anne K. Rehme
- Simone Vossel (ORCID: https://orcid.org/0000-0002-6351-8849)
- Theresa Paul (ORCID: https://orcid.org/0000-0003-0244-7503)
- Corinna Ringmaier
- Lukas J. Volz (ORCID: https://orcid.org/0000-0002-0161-654X)
- Caroline Tscherpel (ORCID: https://orcid.org/0009-0003-6874-0849)
- Scott T. Grafton (ORCID: https://orcid.org/0000-0003-4015-3151)
- F. Esser
- Elke Binder
Institutions
- Goethe University Frankfurt (DE)
- University of California, Santa Barbara (US)
- University of Cologne (DE)
- University of Rochester Medical Center (US)
- Institut des Sciences Cognitives Marc Jeannerod (FR)
- University Hospital Frankfurt (DE)
- University Hospital Cologne (DE)
Publication Details
- Journal
- Stroke
- Published
- 2025-05-20
- DOI
- https://doi.org/10.1161/strokeaha.125.050929
- Citations
- 6
- Primary Topic
- Stroke Rehabilitation and Recovery
- Type
- article
- Field-Weighted Citation Impact
- 6.16